Nevirapine suspension compound recipe

This recipe provides a detailed guide for preparing a nevirapine suspension. Accurate measurement is paramount; use a calibrated measuring device for all ingredients. Begin by meticulously weighing out 100mg of nevirapine powder. Ensure the powder is finely divided for optimal solubility.

Next, add 2.5ml of Ora-Plus^® suspension vehicle to a clean mortar. Gently triturate the nevirapine powder into the vehicle until a smooth, homogenous mixture forms. Avoid vigorous grinding to prevent nevirapine degradation. The Ora-Plus^® helps mask the bitter taste and improves palatability.

Gradually add additional Ora-Plus^® to achieve the desired final volume and concentration. Thorough mixing is critical for a uniform suspension. A final volume of 10ml will yield a 10mg/ml nevirapine suspension. After preparing, store the suspension in a tightly sealed container, protected from light and heat. Remember to always follow proper pharmaceutical compounding practices and adhere to local regulations.

This recipe serves as a guideline. Consult relevant pharmaceutical compendia and other reliable sources for additional information and to ensure compliance with all applicable standards. This information is not a substitute for professional medical advice. Always seek the guidance of a qualified pharmacist or healthcare provider before preparing or administering any medication.

Nevirapine Suspension Compound Recipe: A Detailed Guide

Prepare a nevirapine suspension using these precise measurements for accurate dosage.

Ingredients:

• Nevirapine tablets (200mg): The number of tablets depends on the desired final concentration and volume. Calculate this based on the patient’s prescribed daily dose.
• Purified water: Enough to achieve the desired final volume. Use sterile, purified water for optimal safety and stability.
• Flavoring agent (optional): Strawberry or other palatable flavoring to enhance palatability. Use a pharmaceutical-grade flavoring.
• Thickening agent (optional): If needed for better suspension, add a small amount of a suitable pharmaceutical-grade thickening agent (e.g., xanthan gum). Use sparingly to avoid excessive viscosity.
• Preservative (optional): If the suspension needs to have a longer shelf-life, add a preservative suitable for oral administration. Consult a pharmacist for appropriate choices and concentrations.

Instructions:

1. Carefully crush the nevirapine tablets into a fine powder. Avoid inhaling the powder.
2. Gradually add the purified water to the nevirapine powder, stirring continuously until a smooth suspension is formed. Ensure complete dissolution of the powder to the extent possible.
3. If using, add the flavoring agent and stir thoroughly to mix completely.
4. If using, incorporate the thickening agent slowly, stirring constantly to prevent clumping. Assess the viscosity and adjust as needed.
5. If using a preservative, add it according to the manufacturer’s instructions.
6. Transfer the prepared suspension into a clean, appropriately labeled container. Clearly indicate the concentration of nevirapine, preparation date, and expiration date.
7. Store the suspension in a refrigerator to maintain stability.

Important Notes:

• Always perform accurate calculations to determine the correct amount of nevirapine needed. Consult with a pharmacist for guidance if necessary.
• Strictly adhere to sterile techniques during preparation to minimize the risk of contamination.
• The shelf life of the suspension will depend on the ingredients used, storage conditions, and the presence of a preservative. Consult with a pharmacist for guidance.
• This recipe is a guideline and might need adjustments based on individual patient needs and local guidelines. Always consult a qualified healthcare professional.
• Discard any unused suspension after the determined expiration date.

Understanding Nevirapine and its Suspension Form

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV. It’s typically administered as a tablet, but a suspension is often necessary for patients who can’t swallow pills, particularly children. This suspension allows for accurate dosing based on weight.

Key properties of nevirapine include its relatively low water solubility and its sensitivity to light and air. This necessitates specific formulation considerations for the suspension to ensure stability and efficacy. The suspension’s formulation must counter these properties.

Accurate measurement is vital when preparing and administering nevirapine suspension. Incorrect dosing can affect treatment efficacy. Always follow prescribed guidelines meticulously. Use appropriate measuring devices to ensure accuracy.

Storage instructions are critical. Protect the suspension from light and heat. Store it as directed by the pharmacist or physician. Expiry dates should be strictly adhered to. Discard any unused suspension after the expiry date.

The use of nevirapine suspension presents certain challenges but is a crucial tool for managing HIV in specific patient populations. Adhering to proper preparation, administration, and storage protocols safeguards treatment effectiveness and patient health.

Gathering Necessary Ingredients and Equipment

First, acquire pharmaceutical-grade nevirapine powder. Ensure it meets the required purity standards for compounding. You’ll also need purified water, a suitable suspending agent like methylcellulose or acacia, and a flavoring agent like cherry or orange flavoring syrup to improve palatability. A precise measuring scale, accurate to at least 0.01 gram, is crucial for accurate dosing.

Equipment Checklist

Gather clean and dry glassware, including graduated cylinders, beakers, and a mortar and pestle for mixing. You will also need a sterile syringe and needles for transferring the suspension. A magnetic stirrer with a stir bar can significantly improve mixing efficiency. Finally, you’ll need appropriate containers for storing the finished suspension, clearly labeled with the concentration, preparation date, and expiration date. Sterile conditions are paramount; ensure your work area is clean and use appropriate personal protective equipment (PPE) like gloves and a mask.

Ingredient Sourcing

Source your ingredients from reputable pharmaceutical suppliers. Verify the purity and expiration dates of all materials. Remember that accurate measurement and meticulous attention to detail are paramount for producing a safe and effective medication.

Step-by-Step Preparation of the Nevirapine Suspension

Accurately measure 200 mg of Nevirapine powder. Ensure your scale is calibrated for accuracy.

1. Add 5 ml of purified water to a clean mortar. Gently grind the Nevirapine powder into a smooth paste.
2. Gradually add 45 ml of the suspending agent (e.g., syrup USP or Ora-Plus). Continuously stir to prevent clumping.
3. Transfer the mixture to a 100 ml volumetric flask. Rinse the mortar thoroughly with a small amount of the suspending agent and add the rinsing to the flask.
4. Add more suspending agent to bring the final volume to exactly 100 ml.
5. Mix thoroughly until a uniform suspension is achieved. This may take several minutes of vigorous mixing.

Use a sterile syringe to measure doses. Store the suspension in a tightly sealed amber glass bottle at room temperature. Always shake well before each use.

• Always follow good hygiene practices throughout the preparation process.
• Discard any unused suspension after 14 days.
• Consult relevant guidelines and pharmacopoeias for detailed information and alternative methods.

This recipe provides a concentration of 2 mg/ml. Adjust the amounts of Nevirapine powder and suspending agent accordingly if a different concentration is required.

Ensuring Accurate Dosage and Measurement

Use only calibrated measuring devices. A 1 ml oral syringe with clear markings is ideal. Avoid using household spoons as they lack accuracy.

Always double-check your measurements. Before administering, carefully review the prescribed dosage against your measured amount. Independent verification minimizes errors.

Understanding Concentration

The nevirapine suspension concentration directly impacts dosage. Confirm the concentration printed on your medication label. Misinterpreting the concentration can lead to incorrect dosages.

Practical Measurement Tips

For precise dispensing, draw the suspension into the syringe slowly to avoid air bubbles. Remove any air bubbles before administering the dose.

Ensure the patient receives the full dose. If any medication is left in the syringe, don’t reuse it; instead, discard it appropriately.

Dosage Chart Example

Weight (kg)	Dosage (mg/kg)	Total Daily Dose (mg) (Example: 2mg/kg)
10	2	20
15	2	30
20	2	40

Note: This is a sample chart and your patient’s actual dosage should be determined by a healthcare professional. Always refer to the prescription for accurate dosing information.

Proper Storage

Store the suspension as directed on the label. Incorrect storage can affect its potency and accuracy of dosage.

Proper Storage and Handling of the Prepared Suspension

Store the prepared nevirapine suspension in a refrigerator between 2°C and 8°C (36°F and 46°F). Discard any unused portion after 14 days.

Always use a clean, dry measuring device to administer the correct dose. Avoid using spoons or other household items.

Ensure the suspension is thoroughly mixed before each dose by gently shaking the container. Do not freeze the suspension.

Protect the suspension from direct sunlight and heat. Keep it out of reach of children.

Observe the suspension for any changes in appearance, such as discoloration or clumping. Discard the suspension if you notice any unusual changes.

Consult a pharmacist or healthcare professional for further guidance on proper storage and handling.

Stability and Shelf Life of the Compounded Nevirapine

Compounded nevirapine suspensions are generally stable for 30 days when refrigerated at 2-8°C. This assumes proper compounding techniques and use of appropriate excipients. Always visually inspect the suspension before each use for any changes in color, texture, or the presence of particulate matter. Discard the suspension if any abnormalities are observed.

Light exposure can degrade nevirapine. Store the compounded suspension in an amber glass bottle to minimize degradation from light. Avoid freezing, as this can alter the suspension’s properties.

The specific stability profile might vary depending on the exact formulation and the excipients used. Consult the compounding pharmacy’s stability data, if available, for the most accurate information on the shelf life of your particular batch. Always follow the labeling instructions provided by the compounding pharmacy.

Remember to accurately record the preparation date on the container. Discard any unused suspension after 30 days, regardless of its apparent condition. Patient safety requires adhering to these guidelines for optimal efficacy and to minimize the risk of adverse events.

Important Safety Precautions and Considerations

Always wear gloves when preparing the nevirapine suspension. Direct skin contact should be avoided.

Accurately measure all ingredients using a calibrated measuring device. Inaccurate measurements can significantly affect the drug’s potency and efficacy.

Thoroughly clean and sterilize all equipment before and after compounding. This minimizes the risk of contamination.

Store the prepared suspension in a tightly sealed, light-resistant container at the recommended temperature. Note the expiration date clearly and discard after this date.

Strictly adhere to the prescribed dosage and administration instructions. Never exceed the recommended dose.

Monitor the patient for any adverse reactions, such as rash, nausea, or vomiting. Report any unusual symptoms to the healthcare provider immediately.

Proper disposal of unused medication is vital. Follow local guidelines for safe disposal of pharmaceutical waste.

Keep the compounded suspension out of reach of children and pets. Accidental ingestion can be dangerous.

Consult a qualified pharmacist or healthcare professional for any questions or concerns regarding the preparation or administration of the nevirapine suspension. Their expertise ensures safe and effective use.

This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for diagnosis and treatment.