Sildenafil citrate mol wt

The molecular weight of sildenafil citrate is approximately 664.72 g/mol. This precise figure is crucial for accurate dosage calculations and pharmaceutical analysis.

Understanding this molecular weight allows for precise formulation of medications containing sildenafil citrate. Pharmaceutical scientists rely on this data for quality control, ensuring consistent potency and efficacy in each dosage form. This precise measurement helps maintain product purity and safety.

Remember to always consult reliable scientific databases and pharmaceutical compendia for the most up-to-date and verified molecular weight data. Variations may exist due to isotopic abundances, but 664.72 g/mol serves as a widely accepted and practical value.

Accurate molecular weight determination is fundamental to the development and manufacturing of safe and effective medications. Using the correct molecular weight is paramount for appropriate dosage and pharmaceutical calculations.

Sildenafil Citrate: Molecular Weight and Implications

Sildenafil citrate’s molecular weight is approximately 666.7 g/mol. This precise value is crucial for accurate dosage calculations and pharmaceutical formulation. Understanding this weight helps pharmacists and pharmaceutical scientists precisely control the amount of active ingredient in each dose.

Pharmaceutical Applications

The molecular weight directly impacts drug delivery systems. Formulators consider this value when designing tablets, capsules, or other formulations. For instance, knowing the molecular weight helps determine the appropriate amount of excipients needed to create a stable and bioavailable product. Accurate calculations using the molecular weight ensure consistent drug absorption and efficacy.

Analytical Considerations

In quality control, the molecular weight is vital for analytical techniques like mass spectrometry. This technique verifies the purity and identity of the sildenafil citrate, confirming its correct chemical structure and composition, thus ensuring product safety and efficacy. Deviations from the expected molecular weight indicate potential impurities or degradation.

Calculating the Molecular Weight of Sildenafil Citrate

To calculate the molecular weight of sildenafil citrate, sum the atomic weights of each atom in the molecule. Sildenafil citrate’s chemical formula is C₂₂H₃₀N₆O₄S·C₆H₈O₇. This represents sildenafil (C₂₂H₃₀N₆O₄S) and one molecule of citric acid (C₆H₈O₇).

Atomic Weights

Use the following approximate atomic weights: Carbon (C) = 12.01 amu, Hydrogen (H) = 1.01 amu, Nitrogen (N) = 14.01 amu, Oxygen (O) = 16.00 amu, and Sulfur (S) = 32.07 amu.

Calculation

For sildenafil: (22 * 12.01) + (30 * 1.01) + (6 * 14.01) + (4 * 16.00) + (1 * 32.07) = 664.7 amu. For citric acid: (6 * 12.01) + (8 * 1.01) + (7 * 16.00) = 192.14 amu. Adding these together: 664.7 amu + 192.14 amu = 856.84 amu. Therefore, the molecular weight of sildenafil citrate is approximately 856.84 amu. Note that slight variations might occur depending on the atomic weight values used.

Practical Applications

Accurate molecular weight determination is crucial in pharmaceutical applications, including dosage calculations, formulation development, and quality control. Precise measurements help ensure the safety and efficacy of medications.

Sildenafil Citrate’s Molecular Weight in Pharmaceutical Applications

Sildenafil citrate has a molecular weight of approximately 666.7 g/mol. This precise figure is critical for accurate dosage calculations and formulation development. Pharmaceutical scientists rely on this value for several key applications.

Dosage Formulations

Knowing the molecular weight allows precise determination of the amount of sildenafil base needed in various dosage forms, ensuring consistent drug delivery. This impacts tablet manufacturing, where precise weights of active pharmaceutical ingredient (API) are crucial for achieving the desired potency. Liquid formulations, too, benefit from this accuracy, maintaining consistent drug concentration.

Quality Control and Assay Development

Accurate molecular weight is fundamental to quality control procedures. It underpins analytical methods, such as High-Performance Liquid Chromatography (HPLC), used to determine the purity and concentration of sildenafil citrate in manufactured batches. Deviation from the expected molecular weight signals potential issues in the manufacturing process.

Pharmacokinetic and Pharmacodynamic Studies

The molecular weight influences the pharmacokinetic profile of sildenafil, affecting its absorption, distribution, metabolism, and excretion. Understanding this relationship is crucial for optimizing drug delivery and efficacy. Accurate molecular weight data is therefore essential for modeling drug behavior within the body.

Regulatory Compliance

Regulatory agencies worldwide require precise molecular weight data for drug registration and approval. This information forms a cornerstone of the drug’s characterization and is essential for demonstrating the product’s safety and efficacy.

Impact of Molecular Weight on Sildenafil Citrate’s Pharmacokinetics and Pharmacodynamics

Sildenafil citrate’s molecular weight (approximately 666.7 g/mol) significantly influences its behavior in the body. This weight impacts both its pharmacokinetics (what the body does to the drug) and its pharmacodynamics (what the drug does to the body).

Pharmacokinetics

The relatively high molecular weight contributes to its moderate absorption from the gastrointestinal tract. This means that oral bioavailability isn’t perfect; some drug is lost before reaching the bloodstream.

• Absorption: Absorption rate influences onset of action. Higher molecular weight compounds, like sildenafil citrate, tend to be absorbed slower than smaller molecules.
• Distribution: The molecular weight affects how well the drug distributes throughout the body. Its moderately lipophilic nature, combined with its size, influences its penetration into tissues.
• Metabolism: Sildenafil citrate undergoes hepatic metabolism, primarily via the CYP3A4 enzyme. Molecular size can influence how easily the drug interacts with this and other metabolizing enzymes. This partly determines its half-life.
• Excretion: The majority of sildenafil and its metabolites are excreted via the kidneys, with molecular weight affecting filtration and clearance rates.

Pharmacodynamics

Sildenafil citrate’s molecular weight indirectly influences its pharmacodynamic properties by affecting its concentration at the target site. Its binding to phosphodiesterase-5 (PDE5) is related to its chemical structure, not solely its molecular weight. However, achieving sufficient drug concentrations at the target site–to cause vasodilation–is determined, in part, by its pharmacokinetic profile, which is partially dictated by its size.

1. Target Binding: While molecular weight is not the primary factor in PDE5 binding affinity, it indirectly impacts the drug’s effectiveness by affecting its bioavailability and distribution to target tissues.
2. Efficacy and Duration: The final concentration of sildenafil at the target site directly impacts the efficacy and duration of action, and these are modulated, in part, by its molecular weight-related pharmacokinetic properties.

Therefore, understanding sildenafil citrate’s molecular weight provides valuable insight into its behavior in the body and helps to predict its therapeutic effects and potential side effects. Further research into drug metabolism and transport processes could offer more precise understanding of this relationship.