Tranexamic acid oral suspension recipe

Need a reliable tranexamic acid oral suspension recipe? Prepare a 250mg/5ml suspension by dissolving 25 grams of tranexamic acid powder in 500ml of purified water with the help of a suitable solubilizer like sorbitol or sucrose. Ensure complete dissolution before adding flavoring agents like cherry or orange syrup to mask the taste.

This recipe yields a suspension suitable for administration using a measuring spoon or syringe. Always consult a pharmacist for accurate measurement guidance and dosage recommendations based on individual patient needs. Proper storage is vital – keep the suspension refrigerated, protecting it from light and heat. A tightly sealed container will help maintain its quality and potency.

Important Note: This information serves as a guide only. You must obtain a prescription from a qualified healthcare professional before preparing and administering any medication, including tranexamic acid. Improper preparation or dosage can have serious health consequences. Never self-medicate.

Before using this recipe, carefully review the patient’s medical history and potential drug interactions. Consider using a stabilizer like methylparaben or propylparaben to extend the shelf life of the suspension. Label the final product clearly with the concentration, preparation date, and expiry date.

Tranexamic Acid Oral Suspension Recipe: A Detailed Guide

Prepare a stable, palatable tranexamic acid oral suspension using these steps. This recipe yields approximately 100ml.

Ingredients:

• Tranexamic acid powder: 5 grams (adjust as needed for desired concentration)
• Purified water: 90ml
• Glycerin: 5ml (acts as a stabilizer and sweetener)
• Methylparaben (preservative): 0.18g (0.18% w/v)
• Propylparaben (preservative): 0.02g (0.02% w/v)
• Flavoring agent (e.g., cherry, orange): To taste (adjust according to preference)

Note: Always use pharmaceutical-grade ingredients. Adjust quantities proportionally for different batch sizes.

Preparation:

1. Combine purified water, glycerin, methylparaben, and propylparaben in a clean, sterile container.
2. Stir until the preservatives are completely dissolved. Ensure all ingredients are thoroughly mixed.
3. Gradually add the tranexamic acid powder, stirring continuously to prevent clumping. Use a mortar and pestle if necessary for finer powder dispersion.
4. Once all the powder is incorporated, add the flavoring agent. Stir until evenly distributed.
5. Assess the suspension’s appearance; it should be homogenous and free of lumps.
6. Transfer the prepared suspension to an amber glass bottle for storage to minimize light exposure.
7. Label clearly with the concentration, date of preparation, and expiry date (typically 2 weeks refrigerated).

Important Considerations:

• Maintain strict aseptic techniques throughout the preparation process.
• Store the suspension in a cool, dry place, away from direct sunlight. Refrigerate after preparation to extend shelf life.
• Always consult a qualified pharmacist or healthcare professional before preparing or administering this medication, especially for children or individuals with specific health conditions. This recipe is for informational purposes only and does not replace professional medical advice.
• Discard any unused portion after the expiry date.

This recipe provides a basic framework. Specific needs may require adjustments from a healthcare professional.

Understanding Tranexamic Acid and its Uses

Tranexamic acid is a medication that reduces blood loss. It works by inhibiting the breakdown of blood clots, thus helping to stop bleeding. This makes it useful in various situations.

Medical Applications of Tranexamic Acid

Doctors prescribe tranexamic acid to treat heavy menstrual bleeding (menorrhagia) in women. It’s also effective in managing bleeding after surgery, particularly in procedures like dental extractions or tonsillectomies. Additionally, tranexamic acid shows promise in reducing bleeding associated with trauma, including injuries that cause significant blood loss. Always follow your doctor’s instructions for dosage and duration of treatment.

Important Considerations

Tranexamic acid can interact with certain medications, so inform your doctor about all the drugs you take, including over-the-counter medications and supplements. Rare but serious side effects, such as blood clots, allergic reactions, and seizures, have been reported. Seek immediate medical attention if you experience any unusual symptoms while taking this medication. Proper diagnosis is crucial before using tranexamic acid; it’s not a substitute for professional medical advice.

Ingredients Required for the Oral Suspension

You’ll need pharmaceutical-grade tranexamic acid powder. A typical recipe uses 500mg of tranexamic acid per 5ml of suspension. Precise quantities depend on the desired concentration and total volume.

For the suspending agent, consider using a blend of xanthan gum and sucrose. Xanthan gum provides viscosity, while sucrose offers sweetness and palatability. Experiment to find the ideal ratio for smooth suspension and desirable taste. Typical concentrations range from 0.5% to 1% xanthan gum and 5% to 10% sucrose.

Flavouring agents are critical for masking the somewhat bitter taste of tranexamic acid. Strawberry, orange, or cherry flavors are popular choices. Use food-grade flavoring oils, adjusting the amount to suit your preferences. A small amount of sweetener, such as saccharin or aspartame, may enhance palatability further.

Finally, purified water is used as the solvent. Ensure you use sterile, distilled water to maintain product stability and prevent microbial growth. Dispense the final product into suitable containers with accurate dosing measures.

Remember to consult a pharmacist or qualified healthcare professional for guidance on accurate measurements, compounding techniques, and safety protocols before preparing or administering any medication.

Step-by-Step Preparation of the Tranexamic Acid Oral Suspension

Accurately weigh the required amount of tranexamic acid powder using a calibrated balance.

1. Slowly add a small portion of the chosen suspending agent (e.g., syrup, sorbitol solution) to the tranexamic acid while continuously stirring with a clean spatula or magnetic stirrer to ensure complete wetting and prevent clumping. Use a mortar and pestle for smaller batches, ensuring thorough mixing.
2. Gradually incorporate the remaining suspending agent, maintaining constant stirring until a smooth, homogenous mixture is achieved. The viscosity should be adjusted to the desired consistency.
3. Add flavoring agents (e.g., vanilla extract, fruit flavorings) if needed. Thoroughly mix to ensure even distribution.
4. Transfer the suspension into a clean, sterilized amber glass bottle. Label the bottle clearly with the name of the medication, concentration, preparation date, and expiration date.
5. Store the suspension in a cool, dark place, away from direct sunlight and moisture. Shake well before each use to ensure uniform drug distribution.

For precise measurements and to maintain sterility, consider using appropriate pharmaceutical equipment and adhering to good manufacturing practices (GMP).

• Always consult a pharmacist or qualified healthcare professional for guidance on proper compounding techniques and ensuring the safety and efficacy of the prepared suspension.
• Remember to dispose of any unused portion according to local regulations.

Ensuring Accurate Dosage and Measurement

Use a calibrated oral syringe or measuring spoon designed for medication administration. Never guesstimate! Improper measurement can lead to treatment failure or adverse effects.

Using an Oral Syringe

Always double-check the syringe’s markings before measuring. Ensure you draw the correct volume of tranexamic acid suspension to the prescribed dose. Avoid introducing air bubbles, which can affect accuracy. Gently expel any air bubbles before administering.

Using a Measuring Spoon

If using a measuring spoon, confirm its accuracy against a calibrated device. Level the spoon using a straight edge to ensure you obtain the correct amount. Follow the specific instructions provided with your prescription.

Dosage Chart Example

Patient Weight (kg)	Dosage (ml)
20	5
30	7.5
40	10

This chart is an example only. Always follow your doctor’s or pharmacist’s instructions and the prescribed dosage for your specific situation.

Parental Supervision

Administering tranexamic acid suspension to children requires careful parental supervision. Ensure the correct dose is given and monitor the child for any adverse reactions.

Storage and Handling

Store the suspension as directed on the label, typically in a cool, dark place. Always check the expiration date before use. Discard any unused suspension after the expiration date.

Storage Guidelines for the Prepared Suspension

Store the prepared tranexamic acid oral suspension in a refrigerator between 2°C and 8°C (36°F and 46°F). This temperature range maintains the suspension’s stability and prevents degradation.

Shelf Life

The prepared suspension should be used within 7 days of preparation. Discard any unused portion after this time. Do not freeze the suspension.

Container

Keep the suspension in its original, tightly closed container to prevent contamination and moisture absorption. This helps maintain its potency.

Light Sensitivity

Protect the container from direct sunlight or excessive light exposure. Light can degrade the active ingredient, reducing the medication’s effectiveness. Store it in a dark cupboard if necessary.

Potential Side Effects and Precautions

Tranexamic acid oral suspension, while generally safe, can cause side effects. Common side effects include nausea, vomiting, and diarrhea. These are usually mild and resolve without treatment. Less common, but more serious, are allergic reactions. Symptoms of an allergic reaction might include skin rash, itching, swelling of the face, lips, tongue, or throat, and difficulty breathing. Seek immediate medical attention if you experience any allergic reaction.

Blood Clots

Tranexamic acid can increase the risk of blood clots, especially in individuals with a history of blood clots or those undergoing surgery. Inform your doctor about your medical history, including any bleeding or clotting disorders, before starting treatment. Avoid this medication if you have a known history of deep vein thrombosis or pulmonary embolism. Monitor yourself for symptoms of blood clots like pain, swelling, and redness in your legs or shortness of breath.

Other Precautions

Patients with renal impairment should use caution, as the medication may accumulate in the body. Dosage adjustments may be necessary. Always follow your doctor’s instructions precisely regarding dosage and administration. Do not exceed the recommended dose. Consult your doctor if you are pregnant, breastfeeding, or taking other medications, as interactions are possible. Regular monitoring might be required, depending on your individual condition.

When to Consult a Healthcare Professional

Seek immediate medical attention if you experience severe allergic reactions, such as difficulty breathing, swelling of your face, lips, tongue, or throat, or hives. These symptoms require prompt medical intervention.

Contact your doctor or pharmacist if you notice unusual bruising or bleeding, or prolonged menstrual bleeding after starting tranexamic acid. These could indicate an unexpected side effect or interaction with other medications.

Report any persistent or worsening symptoms, even if they seem minor. This includes but is not limited to nausea, vomiting, diarrhea, dizziness, or headaches. Detailed descriptions of your symptoms will help your healthcare provider determine the best course of action.

Medication Interactions

Always inform your doctor or pharmacist of all medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins. This is particularly important as tranexamic acid can interact with certain medications.

Pregnancy and Breastfeeding

Discuss the use of tranexamic acid with your doctor if you are pregnant, breastfeeding, or planning to become pregnant. The safety and efficacy of this medication during pregnancy and breastfeeding must be evaluated on a case-by-case basis.

Dosage Concerns

Symptom	Action
Missed Dose	Take the missed dose as soon as you remember, unless it’s almost time for the next dose. Do not double the dose.
Overdose	Contact your doctor or local poison control center immediately.

Specific Concerns

If you have a history of blood clots, kidney disease, or liver disease, you must discuss the use of tranexamic acid with your doctor before starting treatment. These conditions can influence the safety and effectiveness of the medication.